Mouse Dentate Gyrus Gene Expression Patterns After Entorhinal Denervation

A transcriptomic dataset from a mouse model of brain injury. The data includes whole-genome expression analysis of the outer molecular layer and granule cell layer at 1, 3, 7, 14, and 28 days post-lesion. It was authored by Jessica Schlaudraff and published on figshare under a CC-BY-4.0 license.

Use Cases

• Modeling temporal dynamics of neuroinflammation based on glial and inflammatory factor expression.
• Investigating synaptic reorganization based on changes in synaptic adhesion and neurotransmission factors.
• Analyzing compensatory plasticity mechanisms based on upregulation of postsynaptic and dendritic membrane regulators.
• Studying metabolic adaptation following injury based on late changes in respiratory and ribosomal translation factors.

Strengths

• Data includes specific temporal sampling at five post-injury time points (1, 3, 7, 14, 28 days).
• Analysis is spatially resolved, comparing two distinct brain layers (OML and GCL).
• The description provides specific gene expression examples with quantified changes (e.g., Sema3e to 60%, Nrp1 3-7 fold).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific mouse model and injury protocol used.

Provenance

Source

figshare

Collection Method

Whole-genome expression analysis on laser-microdissected tissue from a mouse model of perforant path transection.

Time Range

Samples collected at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:46; freshness should be verified.