Gene Expression in Uterine Leiomyoma and Myometrium Stem Cells from Organ Culture

Transcriptional data from a study comparing gene expression programs in normal myometrial and MED12-mutant leiomyoma stem cells during long-term organ culture. The dataset, shared by Paula Vázquez under a CC-BY-4.0 license, was last updated in April 2026. It is a 326.2 KB XLSX file.

Use Cases

• Identify differential gene expression signatures between normal and tumor tissues based on transcriptional profiles.
• Analyze pro-fibrotic extracellular matrix remodeling pathways based on the upregulation of TGFB-regulated genes and integrins.
• Investigate metabolic reprogramming in leiomyomas based on signatures related to carbohydrate degradation and SLC-mediated transport.
• Compare stemness and hypoxia-associated programs based on the induction of HMGA1, HMGA2, and PLAG1.
• Examine vascular homeostasis dysregulation based on the repression of genes like PLPP3 in leiomyoma cultures.

Strengths

• Data is derived from a physiologically relevant long-term organ culture model, as described in the study.
• The dataset includes comparisons of both baseline and cultured tissues for normal and tumor samples.
• Specific molecular findings, such as MED12 mutation persistence and differential HOX gene expression, are highlighted.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 326.2 KB size suggests a limited scope, likely containing summary or selected results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Gene expression analysis from organ cultures of myometrium and leiomyoma tissues.

Time Range

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Freshness

Last updated 2026-04-22 05:35:56; freshness should be verified.

Geography

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