Mouse Proteomic Response to Echinostoma caproni Infection, 4 Weeks Post-Infection

Proteomic analysis of ileal epithelial cells from ICR mice infected with the helminth Echinostoma caproni. The dataset, created by Emma Fiallos and shared under CC-BY-4.0, quantifies differential protein expression linked to metabolic and immunological changes. Findings reveal upregulation of oxidative phosphorylation proteins and downregulation of fatty acid oxidation pathways, indicating host susceptibility mechanisms.

Use Cases

• Identify protein biomarkers of host susceptibility based on differential expression profiles mentioned in the description
• Model metabolic pathway disruptions during intestinal helminth infection based on changes in oxidative phosphorylation and fatty acid β-oxidation
• Investigate epithelial barrier dysfunction based on data concerning tight junction maintenance proteins
• Analyze skewed immune responses based on the described overexpression of antimicrobial peptides and reduction of eosinophil/neutrophil effectors

Strengths

• Proteomic data generated via LC-MS/MS analysis using DDA and SWATH methods, as described.
• Focus on a well-defined experimental model (male ICR mice infected with E. caproni) at a specific time point (4 weeks post-infection).
• Analysis includes bioinformatics tools for differential expression quantification.

Limitations

• Dataset is small (175.1 KB), indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Emma Fiallos.

Collection Method

Proteins were extracted from isolated ileal epithelial cells of infected mice for LC-MS/MS analysis.

Time Range

Samples collected 4 weeks post-infection.

Freshness

Last updated 2026-04-21 04:23:08; freshness should be verified.