SBC8803: Zebrafish Gut-Brain Multi-Omics Data for Anxiolytic Psychobiotic Study

A multi-omics dataset from a zebrafish study investigating the anxiolytic effects of the paraprobiotic Lactobacillus brevis SBC8803. The data includes behavioral metrics, brain transcriptomic profiles, and 16S rRNA amplicon sequencing of intestinal contents, integrated via DIABLO-based analysis. Azusa Kubota authored this dataset, which was last updated on May 21, 2026.

Use Cases

• Analyzing correlations between gut microbiome shifts and brain transcriptomic changes based on the integrated multi-omics analysis.
• Investigating behavioral markers of anxiety-like behavior in zebrafish based on the novel tank test results described.
• Studying the role of microbial metabolic pathways, such as riboflavin and tryptophan metabolism, in serotonin signaling based on the functional predictions.
• Exploring innate gut-brain coordination independent of treatment effects based on the residual correlation analysis findings.

Strengths

• Data integrates three levels of analysis: behavioral, brain transcriptomic, and gut microbiome, as described in the methods.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Analysis includes specific techniques like Gene Set Variation Analysis (GSVA) and DIABLO-based data integration, as detailed in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 32.6 KB, indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Experimental study involving adult male AB-strain zebrafish fed a diet containing heat-killed SBC8803 for 4 weeks, followed by behavioral testing, RNA sequencing, and 16S rRNA amplicon sequencing.

Freshness

Last updated 2026-05-21 05:35:22; freshness should be verified.