Meta-Analysis of Dietary Nitrate Effects on Weight and Cardiovascular Markers

Eight randomized controlled trials involving 199 participants form the basis of this systematic review and meta-analysis. The study, authored by Wenjun Cai and published on figshare, found nitrate supplementation significantly reduced systolic blood pressure and lipid markers but not body weight or BMI. The analysis adhered to PRISMA 2020 guidelines and was registered with PROSPERO.

Use Cases

• Evaluating the efficacy of dietary nitrate on weight management based on aggregated results from 8 RCTs.
• Analyzing the impact of nitrate supplementation on systolic blood pressure based on the reported standardized mean difference.
• Investigating the relationship between nitrate intake and lipid profiles based on reported effects on total cholesterol and triglycerides.
• Assessing publication bias in nutritional intervention studies based on the mention of detected bias for BMI and diastolic blood pressure.

Strengths

• The analysis is based on a systematic review of 8 randomized controlled trials, a recognized gold-standard study design.
• Results include specific statistical measures, such as standardized mean differences and confidence intervals, for key outcomes.
• The work follows PRISMA 2020 reporting guidelines and has a PROSPERO registration, indicating structured methodology.

Limitations

• The dataset is a 17.7 KB document; the underlying tabular meta-analysis data is not directly accessible.
• The total sample size of the included evidence is relatively small at 199 participants.
• Publication bias was detected for some outcomes, which may affect the validity of the pooled results.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of randomized controlled trials sourced from PubMed, Scopus, Web of Science, and Embase.

Time Range

Literature search conducted up to April 2026.

Freshness

Last updated 2026-04-28 05:24:30