Pediatric FUO Etiology and PFAPA/SURF Management in Chinese Hospital

A ten-year retrospective study at Fudan University Children’s Hospital analyzed 442 pediatric Fever of Unknown Origin (FUO) cases from 2014 to 2024. The data details etiological distributions, clinical features like age at onset and attack intervals, and treatment responses for conditions including PFAPA and SURF.

Use Cases

• Analyze the distribution of etiologies, such as infectious diseases versus autoinflammatory diseases like PFAPA and SURF, across the 442 pediatric cases.
• Model the relationship between clinical characteristics, like mean age at onset and attack interval, and disease subtype classification (e.g., SURF periodic vs. non-periodic).
• Evaluate treatment response rates, such as corticosteroid efficacy for PFAPA or OM-85 remission rates, against patient subgroups defined by immune phenotypes and laboratory parameters.
• Investigate correlations between systemic symptoms (fatigue, headache, urticaria) and the non-periodic SURF subtype classification.

Strengths

• Contains data on 442 pediatric patients with a defined 10-year study period (2014–2024).
• Provides specific clinical metrics, including mean age at onset (3.42 years) and median episode intervals (e.g., every 25 days for PFAPA).
• Reports quantified treatment outcomes, such as a 90.5% complete remission rate for tonsillectomy in PFAPA.

Limitations

• The dataset is very small at 10.9 KB, indicating limited scope and likely a summary table rather than raw patient-level records.
• Sample size is confined to a single hospital in China, limiting geographic generalizability.
• Specific column names and row counts for the underlying tabular data are not provided in the input.

Provenance

Source

Fudan University Children’s Hospital.

Collection Method

Retrospective analysis of pediatric FUO cases.

Time Range

2014 to June 2024.

Freshness

Data covers up to June 2024, with the record last updated in March 2026.

Geography

China (single hospital setting).