Genetic Architecture of Parkinson's Disease in Mexico: A Systematic Review

Twenty-four studies involving 7,048 participants provide the first quality-assessed synthesis of genetic Parkinson's disease research in Mexico. The review, published by Oscar Arias-Carrión in 2026, identifies 27 genes and 71 distinct variants, highlighting population-specific findings like the absence of the LRRK2 p.G2019S mutation. It integrates functional analyses from pathways like mitochondrial quality control and dopaminergic signaling.

Use Cases

• Identify population-specific genetic risk factors for Parkinson's disease based on the 8 recurrently associated loci reported.
• Compare variant associations in admixed populations based on the reported absence of the canonical LRRK2 mutation in Mexican cohorts.
• Design follow-up genetic studies based on the methodological heterogeneity and limited ancestry-aware analyses highlighted in the conclusions.
• Investigate functional pathways in Parkinson's disease based on the convergence on mitochondrial, lysosomal, and synaptic processes described.

Strengths

• Systematic review following PRISMA 2020 guidelines, providing a structured synthesis.
• Covers 24 studies with 7,048 total participants (3,367 patients and 3,781 controls).
• Harmonized variant nomenclature using HGNC and dbSNP identifiers for consistency.
• Includes functional interpretation using Gene Ontology, WikiPathways, and network-based analyses.

Limitations

• The dataset is a 14.9 KB DOCX document, indicating a textual summary rather than raw genetic data.
• Row count and column-level documentation are absent; field semantics must be inferred from the text.
• Data may reflect geographic and temporal bias, as it includes studies only from Mexico published between 2004 and February 2025.

Provenance

Source

figshare, authored by Oscar Arias-Carrión.

Collection Method

Systematic review of original studies following PRISMA 2020 guidelines.

Time Range

Studies published between 2004 and February 2025.

Freshness

Last updated 2026-03-17 13:08:41.

Geography

Mexico.