miR-30c-5p/SOCS3 Axis Data for Duchenne Muscular Dystrophy Inflammation

A 15.2 KB document from figshare, authored by Yayu Wang and last updated in May 2026, presents research data on miRNA-mRNA interactions in Duchenne muscular dystrophy. It likely contains results from integrated RNA-seq analyses, differential expression findings, and validation experiments in mdx mice and cell models.

Use Cases

• Validate miRNA-mRNA regulatory networks based on the identified miR-30c-5p/SOCS3 axis
• Analyze inflammatory pathway enrichment based on SOCS3+ cell data from single-cell RNA-seq
• Study metabolic process suppression in dystrophic muscle based on scRNA-seq findings
• Correlate miRNA expression levels with cytokine changes based on TNF-α and IL-10 measurements

Strengths

• Integrated analysis of bulk, small, and single-cell RNA-seq datasets from multiple public repositories
• Functional validation performed in mdx mice, C2C12 myoblasts, and primary skeletal muscle cells
• Clear identification of 100 differentially expressed miRNAs and a key hub gene

Limitations

• Dataset scale is limited to 15.2 KB, suggesting a summary document rather than raw data
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Integrated differential expression analysis, target gene prediction, and functional pathway enrichment from RNA-seq data.

Freshness

Last updated 2026-05-22 05:35:34