Table 3_The role of salivary lactoferrin as a potential biomarker for periodontal disease:

Hoda Tayebi-Hillali's systematic review and meta-analysis, last updated in May 2026, aggregates evidence from 19 studies on salivary lactoferrin as a biomarker for periodontal disease. The work includes a meta-analysis of 11 studies, reporting elevated lactoferrin levels in individuals with periodontal disease compared to healthy subjects. The dataset is a 60.9 KB document summarizing the review's aim, methods, results, and conclusions.

Use Cases

• Assessing the diagnostic potential of salivary lactoferrin based on reported Ratio of Means (ROM) values for different sample types.
• Evaluating methodological heterogeneity in biomarker studies based on the described risk of bias assessments and evidence grading.
• Investigating the response of lactoferrin levels to periodontal treatment based on the reported post-treatment reductions.

Strengths

• Includes a meta-analysis of 11 studies with specific effect size estimates (e.g., ROM=1.77 for unstimulated saliva).
• Systematic review methodology is documented, including a registration identifier (CRD420251017848).
• Analysis covers multiple sample types: unstimulated saliva, stimulated saliva, and gingival crevicular fluid.

Limitations

• The dataset is a 60.9 KB document; the underlying primary data from the 19 reviewed studies is not included.
• Description metadata is limited; actual data quality requires manual inspection after download.
• Meta-analysis of intervention studies was not feasible due to inconsistent protocols and reporting, limiting conclusions on treatment effects.

Provenance

Source

Hoda Tayebi-Hillali via figshare

Collection Method

Systematic review and meta-analysis of studies from five databases up to January 2026.

Time Range

Studies included up to January 2026; publication date of the review is 2026.

Freshness

Last updated 2026-05-22 05:52:05; freshness should be verified.