Interventions Affecting Next-Generation Epigenetic Aging Clocks in Humans

Table 3_Turning back time is a systematic review of 41 human studies examining the effects of interventions on next-generation epigenetic aging clocks. The dataset, authored by Adiv A. Johnson and last updated in May 2026, lists interventions that decrease, have no effect on, or accelerate epigenetic age. It includes effect sizes and compares the responsiveness of different next-generation clocks.

Use Cases

• Identify promising longevity interventions based on reported decreases in epigenetic age.
• Compare the relative effect sizes of different interventions like exercise, diet, and pharmaceuticals.
• Assess the frequency of use and responsiveness of specific next-generation epigenetic clocks mentioned in the review.

Strengths

• Systematically compiled from 41 identified human studies, providing a structured overview.
• Focuses on next-generation epigenetic clocks, which are more strongly associated with mortality risk than first-generation clocks.
• Explicitly lists interventions with positive, null, and negative effects on epigenetic aging.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The 18.8 KB file size suggests a limited scope, likely a summary table rather than raw study data.

Provenance

Source

Adiv A. Johnson via figshare

Collection Method

Systematic searches and review of published human studies.

Freshness

Last updated 2026-05-28 22:03:24