Sea Urchin Immune Cell Transcriptional Response to UVB-Induced DNA Damage

16.5 KB of tabular data from figshare details the transcriptional response of purple sea urchin immune cells to UVB-induced genotoxic stress. The dataset likely contains results from single-cell RNA sequencing and functional assays performed by Riss M. Kell, published in March 2026. It demonstrates concurrent activation of DNA damage response and innate immune pathways in a cancer-resistant invertebrate.

Use Cases

• Identify conserved DDR gene activation patterns based on transcriptional response data.
• Analyze cell-type-specific responses to UVB challenge based on single-cell RNA sequencing results.
• Investigate post-translational modification pathways based on ubiquitination and phosphorylation substrate data.
• Compare invertebrate damage recognition systems based on innate immune pathway activation.

Strengths

• Data is derived from single-cell RNA sequencing, a high-resolution technique.
• Focuses on a long-lived, cancer-resistant model organism (Strongylocentrotus purpuratus).
• Includes validation from functional assays and western blot analysis.
• Published under an open CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (16.5 KB), indicating limited scope.

Provenance

Source

figshare, authored by Riss M. Kell.

Collection Method

Likely generated from laboratory experiments including UVB exposure, single-cell RNA sequencing, and functional assays.

Freshness

Last updated 2026-03-19 05:18:34.