Table 4_A Bayesian network meta-analysis: evaluating the efficacy and safety of targeted t

9 randomized controlled trials involving 1,760 patients with advanced radioiodine-refractory differentiated thyroid cancer were analyzed. The dataset contains results from a Bayesian network meta-analysis comparing the efficacy and safety of targeted therapies, including lenvatinib, anlotinib, apatinib, and cabozantinib. It was authored by Pin Wang and uploaded to figshare on 2026-03-18.

Use Cases

• Compare progression-free survival hazard ratios between targeted therapies based on the reported Bayesian network meta-analysis results.
• Rank treatment efficacy for objective response rate using the provided surface under the cumulative ranking curve (SUCRA) values.
• Assess the safety profile of different tyrosine kinase inhibitors based on the analysis of grade ≥3 adverse events.
• Investigate time-dependent efficacy patterns of treatments like apatinib, which showed early advantage but waning efficacy.

Strengths

• Analysis is based on 9 randomized controlled trials, a standard for clinical evidence.
• Includes results for 1,760 patients, providing a substantial sample for the meta-analysis.
• Reports multiple clinical endpoints: progression-free survival, overall survival, objective response rate, and adverse events.
• Employs Bayesian network meta-analysis, allowing for indirect comparisons between treatments not directly tested in head-to-head trials.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is 46.5 KB, indicating a very limited scope, likely containing summary statistics rather than patient-level data.
• Data may reflect publication bias inherent to the systematic review and meta-analysis process.

Provenance

Source

figshare, author Pin Wang.

Collection Method

Systematic search of six electronic databases and subsequent Bayesian network meta-analysis of identified randomized controlled trials.

Freshness

Last updated 2026-03-18 07:35:10; freshness should be verified.