Gene Expression Patterns Modulated by TB-Derived Exosomal miRNAs in Lung Cancer

Goeun Park's dataset on figshare contains analysis of miRNA-mRNA regulatory pathways linking tuberculous pleural effusion to lung cancer progression. The data includes five differentially expressed miRNAs and 54 differentially expressed genes identified from exosomes and xenograft models. The dataset was last updated on 2026-05-28 and is shared under a CC-BY-4.0 license.

Use Cases

• Constructing miRNA-mRNA interaction networks based on the 94-gene regulatory network described.
• Performing pathway enrichment analysis based on oxidative phosphorylation and ribosome biogenesis terms identified.
• Validating in silico findings on cancer-related genes like NDUFA4, RPS27, and COX7A2 mentioned in the description.

Strengths

• Dataset is focused on a specific molecular interaction, with 5 DEMs and 54 DEGs explicitly quantified.
• Analysis includes in vitro validation of identified genes, suggesting experimental grounding.
• Data is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 11.1 KB, indicating limited scope.

Provenance

Source

Goeun Park via figshare.

Collection Method

Exosomes were isolated from patient tuberculous pleural effusions and injected into lung cancer xenograft mice; differential expression analysis and network modeling followed.

Freshness

Last updated 2026-05-28 22:03:25; freshness should be verified.