Table 4_ANCA-associated vasculitis is associated with an increased risk of cardiac and vas

26,329 patients with granulomatosis with polyangiitis or microscopic polyangiitis were propensity-matched to controls in a retrospective cohort study using US electronic health records. The analysis found a threefold increased hazard of death and a significantly higher risk for major adverse cardiovascular and thromboembolic events in patients with ANCA-associated vasculitis. Sebastian Klapa authored this study, which was last updated in April 2026.

Use Cases

• Calculate hazard ratios for mortality and cardiovascular events based on the reported propensity-matched cohort results.
• Compare cardiovascular risk profiles between granulomatosis with polyangiitis and microscopic polyangiitis patient groups.
• Validate findings on increased thromboembolic event risk in ANCA-associated vasculitis using the reported hazard ratios.
• Assess the impact of demographic and comorbidity matching on cardiovascular outcome studies in autoimmune conditions.

Strengths

• Includes results for 20,422 GPA and 5,907 MPA patients, providing a substantial cohort size.
• Uses propensity score matching for demographic variables and comorbidity to optimize between-group comparability.
• Reports specific hazard ratios for death, MACE, and thromboembolic events, offering concrete quantitative findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 26.9 KB DOCX file, suggesting it contains summary results rather than the underlying patient-level data.

Provenance

Source

Electronic health records database of the US-based TriNetX network.

Collection Method

Retrospective cohort study with propensity score matching and Kaplan-Meier/Cox regression analysis.

Time Range

The description does not specify the study's temporal coverage.

Freshness

Last updated 2026-04-15 05:45:58; freshness should be verified.

Geography

Data is from a US-based network, suggesting a primary US patient population.