A genome-wide association study identified three BMI-associated loci reaching genome-wide significance in 1,079 admixed Brazilian individuals. Samantha Kuwada Teixeira authored this dataset, which highlights a non-coding variant enriched in African ancestry that modulates adipogenesis via the KCNB1 gene. The data was last updated on May 7, 2026.
Use Cases
- Validate BMI-associated loci identified in admixed populations based on GWAS results.
- Investigate ancestry-specific genetic mechanisms of obesity based on the enrichment of the rs149309426 risk allele.
- Study the regulatory role of KCNB1 in adipogenesis based on functional assays described.
- Integrate epigenomic annotation and chromatin conformation data for variant prioritization.
- Compare genetic findings across populations based on the rarity of the risk allele in Europeans.
Strengths
- Includes results from a genome-wide association study of 1,079 individuals.
- Integrates functional validation data from luciferase assays, EMSA, and animal models.
- Focuses on an admixed Brazilian population, providing data underrepresented in genetics.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is 60.6 KB, indicating a limited scope of data.
Provenance
- Source
- figshare
- Collection Method
- Genome-wide association study and integrative functional analysis.
- Freshness
- Last updated 2026-05-07 04:45:00; freshness should be verified.
- Geography
- Brazil