Table 4_Association between circulating biomarkers of one-carbon metabolism and glymphatic

A dataset of 210 participants investigates the relationship between circulating biomarkers of one-carbon metabolism and glymphatic system function in Alzheimer's disease. The study includes 68 normal cognition, 75 mild cognitive impairment due to AD, and 67 dementia due to AD participants, with data on serum folate, vitamin B12, homocysteine, and DTI-ALPS index. Yali Chen authored this research, which was last updated on May 11, 2026.

Use Cases

• Correlating serum folate levels with glymphatic function based on the DTI-ALPS index.
• Analyzing domain-specific cognitive performance associations with biomarker levels.
• Comparing cognitive outcomes between risk groups defined by folate and DTI-ALPS index levels.
• Investigating subgroup differences in biomarkers and glymphatic function by sex and age.

Strengths

• Includes data from 210 participants across three clinical groups.
• Measures multiple biomarkers (folate, vitamin B12, homocysteine) and a neuroimaging index (DTI-ALPS).
• Reports statistically significant correlations (e.g., folate and DTI-ALPS index, r=0.212).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 22.1 KB file size suggests a very limited scope, likely containing summary statistics rather than raw participant data.

Provenance

Source

figshare

Collection Method

Clinical study involving biomarker measurement, neuroimaging (DTI-ALPS index), and neuropsychological assessment.

Freshness

Last updated 2026-05-11 04:29:17; freshness should be verified.