Association Between CTI and Rapid Kidney Decline in Chinese Adults Aged 45+

6,888 individuals from the China Health and Retirement Longitudinal Study (CHARLS) were analyzed over a four-year period to explore links between a metabolic-inflammatory index and kidney health. The study found a 3.8% incidence of rapid kidney function decline, with each unit increase in the cumulative CTI index raising the odds by 18%. Lina Huang authored this prospective cohort study, which was last updated in April 2026.

Use Cases

• Modeling risk of rapid kidney function decline based on cumulative changes in the C-reactive protein-triglyceride glucose index.
• Conducting subgroup analyses for kidney disease risk based on demographic and health factors like sex, smoking, and diabetes.
• Validating clinical associations using supplementary cross-sectional data from the NHANES survey.
• Analyzing dose-response patterns between inflammatory/metabolic markers and estimated glomerular filtration rate (eGFR).

Strengths

• Data from 6,888 individuals provides a substantial cohort for analysis.
• Results were validated with sensitivity analyses across original, imputed, and pooled datasets.
• Supplementary analysis used NHANES data to examine similar associations.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 18.0 KB, indicating limited raw data scope.

Provenance

Source

China Health and Retirement Longitudinal Study (CHARLS) and supplementary National Health and Nutrition Examination Survey (NHANES) data.

Collection Method

Multivariate logistic regression and restricted cubic spline models applied to a nationwide prospective cohort.

Time Range

Covers data from 2011 and 2015 waves of CHARLS, with a four-year follow-up period.

Freshness

Last updated 2026-04-13 05:21:06; freshness should be verified.

Geography

China, with supplementary analysis from the United States (NHANES).