UK Biobank Physical Activity and Inflammatory Bowel Disease Risk Study

Yitian Wei published a prospective cohort study on figshare in May 2026 analyzing data from 293,578 UK Biobank participants. The research evaluates the longitudinal relationship between self-reported physical activity intensity and the incidence of Crohn's disease and ulcerative colitis. The dataset contains results from multivariable Cox regression models and restricted cubic spline analyses.

Use Cases

• Assessing the protective effect of total physical activity on Crohn's disease risk based on the study's findings.
• Investigating the nuanced, intensity-dependent relationship between physical activity and ulcerative colitis risk.
• Validating multivariable Cox proportional hazards regression models for longitudinal health outcomes.
• Examining non-linear associations using restricted cubic spline curves as described in the methodology.

Strengths

• Large-scale cohort of 293,578 participants from the UK Biobank.
• Prospective study design with follow-up period and linked hospital admission and death registry records.
• Analysis includes multivariable Cox regression and restricted cubic spline curves for non-linear associations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the UK Biobank source.

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study using self-reported physical activity data and linked hospital admission and death registry records.

Freshness

Last updated 2026-05-14 05:23:51; freshness should be verified.

Geography

United Kingdom