Table 4_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

A study analyzing the association between NDRG4 gene methylation in peripheral blood leukocytes and gastric cancer risk, chemotherapy efficacy, and patient prognosis. The dataset includes results from a two-phase case-control study with 310 gastric cancer patients and 300 controls, along with bioinformatics analyses from TCGA and GEO databases. The research was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Identifying epigenetic biomarkers for gastric cancer risk based on NDRG4 methylation levels at specific CpG sites.
• Predicting chemotherapy efficacy in gastric cancer patients based on methylation patterns described in the study.
• Analyzing the association between gene methylation and progression-free survival (PFS) in cancer prognosis.
• Investigating the relationship between genetic variation (SNP rs7202037) and methylation levels of the NDRG4 gene.

Strengths

• Includes data from a two-phase case-control study with 310 gastric cancer patients and 300 controls.
• Reports specific statistical associations, such as odds ratios (e.g., OR=2.536) and p-values for methylation sites linked to cancer risk.
• Integrates findings from established public databases like TCGA and GEO for bioinformatics validation.

Limitations

• Dataset scale is limited to 19.0 KB, suggesting a small, summary-level dataset rather than raw individual records.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

figshare, authored by Zhan Li.

Collection Method

Case-control study and bioinformatics analysis utilizing TCGA and GEO databases.

Freshness

Last updated 2026-04-27 04:12:26; freshness should be verified.