Table 4_Bushen Huoxue recipe restores trophoblast proliferation through the PI3K/AKT pathw

155 chemical constituents of the Traditional Chinese Medicine formula Bushen Huoxue Recipe were identified for treating recurrent spontaneous abortion. Transcriptome sequencing and network pharmacology analysis identified 267 therapeutic targets, with experimental validation showing reduced embryonic loss in a mouse model. The dataset, shared under a CC-BY-4.0 license, contains results linking the formula's efficacy to the PI3K/AKT signaling pathway.

Use Cases

• Validate network pharmacology predictions based on the 267 identified therapeutic targets for RSA.
• Analyze transcriptomic changes associated with trophoblast proliferation based on the described PI3K/AKT pathway findings.
• Correlate chemical constituents with biological activity based on the 155 identified compounds in BSHXR.
• Benchmark experimental outcomes in miscarriage models based on the reported embryo loss rate and hormone level data.

Strengths

• Dataset is derived from multi-method validation including UPLC–Q–TOF–MS/MS, transcriptome sequencing, and in vivo mouse model experiments.
• Results include statistically significant findings (p < 0.01, p < 0.05, p < 0.0001) for key metrics like embryo loss rate and protein expression.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 315.8 KB file size indicates a limited scope of data, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, authored by Jingheng You.

Collection Method

Data generated through laboratory experiments including chemical analysis, transcriptome sequencing, network pharmacology, and in vivo modeling.

Freshness

Last updated 2026-04-21 05:36:19; freshness should be verified.