Table 4_Clinical characteristics and individualized treatment strategies for children with type 1 diabetes and exogenous insulin antibody syndrome: a retrospective case series and literature review.xlsx

A retrospective case series documents clinical data for five pediatric patients diagnosed with type 1 diabetes complicated by exogenous insulin antibody syndrome. The dataset includes demographics, laboratory findings, treatment regimens, and outcomes from a single center between 2016 and 2026. Author Liang Zhang published the data on figshare in 2026.

Use Cases

• Analyze the relationship between insulin antibody titer levels and glycemic variability metrics like Time in Range (TIR) and Time Below Range (TBR).
• Compare the effectiveness of different insulin regimens (e.g., pump therapy vs. multiple daily injections) on achieving TIR >70% across patient cases.
• Investigate the longitudinal impact of immunosuppressant mycophenolate mofetil (MMF) on antibody titers and C-peptide levels in a refractory case.
• Correlate patient age and clinical manifestations with individualized treatment strategies, such as ultra-rapid insulin dosing frequency.

Strengths

• Longitudinal data includes autoantibody profiles, thyroid function, and cytokines assessed at four time points per patient.
• Dataset provides detailed, patient-level treatment outcomes including specific insulin types, doses, and CGM metrics.

Limitations

• Extremely small sample size of only 5 patients from a single center limits statistical power and generalizability.
• Observational, retrospective design without a control group, as noted by the authors, restricts causal inference.

Provenance

Source

figshare, authored by Liang Zhang.

Collection Method

Retrospective case series review of medical records from a single clinical center, supplemented by a PRISMA-guided literature review.

Time Range

Patient data collected between January 2016 and January 2026.

Freshness

Data covers patients up to January 2026 and was last updated in March 2026.

Geography

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