Clinical Practice Guidelines for Early Psychosis Intervention: An AGREE II Appraisal

A systematic review and appraisal of 26 international clinical practice guidelines and quality standards for early intervention in psychosis. The documents, published from 2005 onward, were evaluated using the AGREE II methodology to identify 32 core service components for clinical high-risk and first-episode psychosis populations. The dataset, a 17.9 KB DOCX file, was authored by Pasquale Scognamiglio and last updated in June 2026.

Use Cases

• Benchmarking local service models against internationally endorsed components for early psychosis care.
• Informing the development of new clinical guidelines based on synthesized recommendations from 26 documents.
• Analyzing methodological quality and gaps in existing guidance using AGREE II domain scores.
• Identifying consensus treatment approaches, such as cognitive-behavioural therapy for at-risk youth or supported employment for first-episode psychosis.

Strengths

• Includes 26 documents (24 clinical practice guidelines and 2 quality standards) providing a broad international perspective.
• Applies a formal, structured methodology (AGREE II) for quality appraisal with inter-rater agreement assessed.
• Synthesizes findings into 32 core recommendations, clarifying consensus on service components.
• Systematic review protocol was pre-registered (OSF identifier cek7u), enhancing methodological transparency.

Limitations

• The dataset is a 17.9 KB DOCX document, indicating a very limited scope focused on review findings rather than raw guideline data.
• Row and column structure is unknown; the data is presented as a review document, limiting direct computational analysis.
• Included documents are limited to English or Italian, which may introduce language and geographic bias.

Provenance

Source

Systematic review of MEDLINE, Cochrane Library, Web of Science, guideline repositories, and grey literature.

Collection Method

Systematic review and AGREE II-based appraisal of documents published from 2005 to March 2025.

Time Range

Guidelines published from 2005 onward, with literature search up to March 2025.

Freshness

Last updated 2026-06-03 06:02:24.

Geography

International (guidelines from multiple jurisdictions).