Penicillin-Resistant Streptococcus Pneumoniae Genomes for Target Discovery, 1996-2022

665 genomes of penicillin-resistant Streptococcus pneumoniae from Indian clinical isolates collected between 1996 and 2022 were analyzed. The dataset likely contains results from an integrated in silico strategy including pangenome construction, GWAS, and structural modeling. It was authored by Avani Panickar and last updated in April 2026.

Use Cases

• Identifying gene clusters associated with penicillin resistance based on genome-wide association studies
• Prioritizing candidate drug targets based on essentiality screening and druggability assessment
• Analyzing evolutionary conservation of potential targets across the 665 genomes
• Modeling protein structures and binding pockets for identified targets like OppC2

Strengths

• Includes 665 high-quality genome assemblies from a defined temporal range (1996-2022)
• Integrated analysis combines genomics, GWAS, network analysis, and structural modeling
• Results identify a specific, highly favorable drug target (OppC2) with supporting evidence

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic bias inherent to the Indian clinical isolates

Provenance

Source

figshare

Collection Method

Genomic analysis of clinical isolates; in silico integration of genomics, GWAS, network analyses, and membrane protein simulations.

Time Range

1996-2022

Freshness

Last updated 2026-04-29 05:54:28; freshness should be verified

Geography

India