ART-Induced Senescence-Like Reprogramming in Alveolar Macrophages

Vinicius M. Fava's dataset on figshare contains results from a systems immunology study evaluating the long-term impact of continuous antiretroviral therapy (ART) on alveolar macrophages. The data, last updated in April 2026, likely includes transcriptomic and epigenetic measurements showing ART induces a progressive senescence-like pro-inflammatory state. The 16.6 MB XLSX file is licensed under CC-BY-4.0.

Use Cases

• Modeling the relationship between ART duration and pro-inflammatory gene expression based on the described progressive changes.
• Analyzing coordinated gene regulatory networks in immune cells based on the single nucleus data mentioned.
• Investigating the impact of ART on interferon signaling and antiviral response based on the described impairment to SARS-CoV-2 challenge.
• Comparing cellular states between people with HIV and people on PrEP based on the study's participant groups.

Strengths

• Dataset is 16.6 MB, indicating a focused and manageable size for analysis.
• Data is licensed under the permissive CC-BY-4.0 license.
• The description provides a detailed scientific context for the research findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Vinicius M. Fava via figshare

Collection Method

Systems immunology approach evaluating alveolar macrophages from people with HIV and people on PrEP.

Freshness

Last updated 2026-04-22 05:49:11; freshness should be verified.