DNER in Renal Cell Carcinoma: Supporting Data for JAK2/STAT3 Signaling Study

DNER was identified as a hub gene linking metabolic reprogramming to immune suppression in clear cell renal cell carcinoma. Supporting data for this finding, authored by Anrui Li, was last updated on May 22, 2026. The 88.7 KB document likely contains bioinformatic and experimental results from a study published on figshare.

Use Cases

• Validate DNER's role in ccRCC progression based on bioinformatic screening results described.
• Investigate the link between glycolytic flux and macrophage polarization based on the described signaling cascade.
• Explore potential sensitivity to PARP inhibitors like Olaparib based on preliminary evidence mentioned in the results.

Strengths

• Data is associated with a specific mechanistic finding (DNER activates JAK2/STAT3) described in detail.
• The dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The dataset is a single 88.7 KB DOCX file, indicating a very limited data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, authored by Anrui Li.

Collection Method

Integrated bioinformatic analyses with in vitro and in vivo experimental validation, as described.

Freshness

Last updated 2026-05-22 06:09:51; freshness should be verified.