Meta-Analysis of Astragalus mongholicus Bunge for Wound Healing in Animal Models

A systematic review and meta-analysis of 21 preclinical animal studies involving 559 animals, evaluating the efficacy and safety of the botanical drug Astragalus mongholicus Bunge for wound healing. The analysis, conducted by Jun Zhang and registered in PROSPERO, found the treatment significantly improved wound contraction, angiogenesis, and collagen deposition. The document was last updated on 2026-04-17.

Use Cases

• Assessing the pooled therapeutic effect of Astragalus mongholicus Bunge on wound contraction percentage based on the meta-analysis results
• Evaluating the impact on biological markers like angiogenesis and collagen deposition based on the systematic review findings
• Informing the design of future preclinical and clinical trials based on the safety and efficacy conclusions

Strengths

• Analysis is based on 21 randomized controlled animal studies, providing a structured evidence base
• Includes data from 559 animals, offering a quantifiable scale for the meta-analysis
• Uses a formal risk of bias assessment tool (SYRCLE) and is registered in PROSPERO (CRD420250641262)

Limitations

• The primary data file is a 540.7 KB DOCX document; the underlying tabular meta-analysis data is not directly accessible
• Row count and column-level documentation for any underlying data are unknown
• Freshness should be verified as the last update date is in the future (2026-04-17)

Provenance

Source

Jun Zhang, published on figshare

Collection Method

Systematic search of seven databases for randomized controlled animal studies, followed by meta-analysis using R software

Freshness

Last updated 2026-04-17 05:08:54