Dose-Dependent Effects of TWG on Arthritis, Lung Injury, and Gut Microbiota in Rats

82.5 KB of experimental data from a study on Tripterygium wilfordii glycosides (TWG) in collagen-induced arthritis rats. The dataset likely contains results from histopathology, cytokine expression, and 16S rRNA sequencing, showing dose-dependent protective effects on joints and lungs linked to gut microbiota changes. It was authored by Shangwen Qi and last updated on April 23, 2026.

Use Cases

• Analyzing dose-response relationships for drug efficacy based on the described low, medium, and high dose groups.
• Investigating correlations between gut microbiota composition and disease pathology based on 16S rRNA sequencing results.
• Modeling anti-inflammatory and anti-fibrotic effects based on IL-6, TNF-α, TGF-β1, and α-SMA biomarker data.
• Comparing therapeutic efficacy against a standard treatment (prednisolone) as described in the experimental design.

Strengths

• Data is derived from a controlled animal study with six distinct treatment groups, including a standard drug control.
• Multiple experimental modalities are integrated, including histology, gene expression, protein analysis, and microbiome sequencing.
• The dataset is openly available under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (82.5 KB), indicating limited scope, likely containing summary or processed results rather than raw sequencing reads.

Provenance

Source

figshare, authored by Shangwen Qi.

Collection Method

Data generated from a controlled laboratory experiment using a collagen-induced arthritis rat model, with treatments administered by oral gavage.

Time Range

The experimental timeline suggests data collection occurred over a 43-day period.

Freshness

Last updated 2026-04-23 05:27:25; freshness should be verified.