Network Meta-Analysis of Diabetic Foot Ulcer Non-Pharmacological Interventions

A 2026 network meta-analysis by Jiaxing Zheng synthesizes results from 24 randomized controlled trials evaluating 15 types of non-pharmacological interventions for diabetic foot ulcer healing. The analysis compares interventions on outcomes like 12-week healing rate and healing time, using data extracted from eight academic databases.

Use Cases

• Rank intervention efficacy for 12-week healing rate using SUCRA scores from the network meta-analysis.
• Compare healing time outcomes across 15 intervention types, such as Negative Pressure Wound Therapy + Standard Care.
• Assess the certainty of evidence by examining reported confidence intervals and risk of bias evaluations.
• Identify promising intervention combinations, like Gas Therapy + Dressing Therapy + Standard Care, for further clinical study.

Strengths

• Synthesizes data from 24 randomized controlled trials, a foundational evidence base for the condition.
• Evaluates 15 distinct non-pharmacological intervention types for comparative analysis.
• Systematically sourced from eight major databases including PubMed, Embase, and Cochrane.
• Includes formal quality evaluation using the Cochrane risk of bias assessment tool (RoB 2.0).

Limitations

• Evidence certainty is limited as noted by the authors, relying on a small number of trials with wide confidence intervals.
• The dataset is a 15.4 KB document, containing only the analysis summary and not the underlying raw trial data.
• Conclusions are exploratory, based on a network meta-analysis of existing small-sample studies.

Provenance

Source

figshare, authored by Jiaxing Zheng.

Collection Method

Systematic review and network meta-analysis of randomized controlled trials from eight academic databases.

Time Range

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Freshness

Last updated March 2026.

Geography

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