Meta-Analysis of Probiotic Effects on Diabetic Kidney Disease from 11 RCTs

A systematic review and meta-analysis of randomized controlled trials published from database inception to July 2025, evaluating probiotic supplementation in patients with diabetic kidney disease. The document, authored by Zhi-Qing Huang and last updated in May 2026, synthesizes results from 11 studies involving 726 participants. It reports effects on renal function, glycemic control, lipid profiles, and inflammatory markers.

Use Cases

• Summarizing clinical evidence for probiotic efficacy based on reported outcomes like serum creatinine and estimated glomerular filtration rate.
• Analyzing treatment effects on metabolic parameters based on reported changes in fasting plasma glucose and glycated hemoglobin.
• Investigating links between probiotics and systemic inflammation based on reported markers like high-sensitivity C-reactive protein and malondialdehyde.

Strengths

• Includes results from 11 randomized controlled trials with 726 total participants.
• Reports specific statistical outcomes (e.g., mean differences and p-values) for multiple clinical and biochemical parameters.
• Uses a defined methodology including seven databases and the Cochrane Risk of Bias tool for quality assessment.

Limitations

• The dataset is a 23.2 KB DOCX file, indicating a limited scope likely containing only the review's text and summary tables.
• Row count and column-level documentation are unknown, limiting suitability assessment for structured analysis.
• The underlying primary data from the included studies is not directly accessible.

Provenance

Source

figshare, authored by Zhi-Qing Huang.

Collection Method

Systematic review and meta-analysis of randomized controlled trials identified from seven databases.

Time Range

Literature from database inception to July 2025.

Freshness

Last updated 2026-05-20 05:44:21; includes literature up to July 2025.