Cathepsin L Gene Expression Profiles in Common Carp During Infection

Sagar Nayak's dataset catalogs nine cathepsin L paralogs in common carp, detailing their expression divergence across tissues and immune compartments. It includes structural modeling predictions and profiles of proteolytic reprogramming during infection with the myxozoan pathogen Sphaerospora molnari. The dataset was uploaded to figshare in April 2026.

Use Cases

• Analyze tissue-specific expression patterns of ctsl.1A/B and ctslaA/B paralogs to infer functional specialization.
• Model structural variation in protease loop architecture and active-site cleft geometry to predict divergent substrate preferences.
• Correlate ctsl transcript dynamics with inflammatory cytokine induction during Sphaerospora molnari infection time courses.
• Examine expression partitioning of ctsl duplicates in mucosal barriers versus systemic immune hubs like blood and head kidney leukocytes.

Strengths

• Profiles nine distinct cathepsin L paralogs retained from whole-genome duplication events.
• Includes expression data partitioned across multiple tissues and immune compartments.
• Contains structural modeling predictions for protease variants.

Limitations

• Small dataset at 3.5 MB, suggesting limited quantitative scope.
• Unknown row count and specific column structure limits assessment of statistical power.
• Data is contained in a DOCX file, which is not a standard format for structured bioinformatics analysis.

Provenance

Source

Sagar Nayak via figshare.

Collection Method

Gene identification, expression profiling, and structural modeling from the common carp model, likely involving RNA sequencing and computational analysis.

Time Range

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Freshness

Last updated in April 2026.

Geography

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