Influenza A(H1N1) Evolutionary Trajectory and Co-detection Analysis (2000–2025)

2000–2025 evidence-mapping synthesis integrates 11,848 unique publications and GenBank-derived hemagglutinin sequences to analyze H1N1 evolutionary dynamics and co-detection patterns. The study, authored by Xinrui Cao, identifies mutational shifts post-2010 and maps frequently reported co-pathogens like RSV and SARS-CoV-2. It employs expert-guided curation and structural modeling to interpret findings for surveillance frameworks.

Use Cases

• Analyze post-2010 mutational landscape shifts in hemagglutinin at specific sites like S13, S146, S160, and S202 from sequence data.
• Map literature-derived co-detection records to identify frequently reported co-pathogens such as RSV and SARS-CoV-2.
• Prioritize specific mutations like G219A in Eurasian avian-like H1N1 strains using expert annotation and isolate-level evidence.
• Compare homology models of hemagglutinin to study the conformationally flexible segment spanning residues aa190–aa226.
• Examine bibliometric trends across 11,848 publications to track research evolution and surveillance priorities over 25 years.

Strengths

• Analysis integrates 11,848 unique publications retrieved from major databases (PubMed, Web of Science, Scopus).
• Temporal coverage spans 25 years (2000–2025) for tracking evolutionary and research trends.
• Evidence synthesis combines bibliometric analysis, expert curation, and sequence/structure-informed interpretation.

Limitations

• The 16.1 KB file size indicates the dataset is a summary document, not the underlying raw sequence or publication data.
• Co-detection records reflect heterogeneous study reporting composition rather than population-level prevalence.
• China-focused module analysis is protocol-constrained, requiring specific isolate-level evidence, limiting generalizability.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of retrieved publications, expert-guided curation, and analysis of GenBank-derived HA sequences and homology models.

Time Range

2000–2025

Freshness

Last updated March 2026.

Geography

Global scope with a specific module focused on China.