Canine Serum Proteome Response to Oral Cannabidiol Across Three Delivery Matrices

18 healthy dogs were studied to characterize the systemic molecular effects of cannabidiol (CBD) in veterinary medicine. Label-free quantitative proteomics compared serum proteomic responses after 30 days of oral CBD delivery via three distinct matrices: hemp by-product feed pellets, CBD-infused oil, and a semi-solid treat. The analysis revealed distinct formulation-specific proteomic signatures and a core metabolic response involving lipid metabolism and redox homeostasis.

Use Cases

• Compare proteomic signatures based on CBD delivery matrix (feed pellets, oil, treat) as described.
• Identify biomarkers of CBD-mediated modulation of lipid metabolism based on apolipoprotein changes.
• Investigate markers of vascular integrity and tissue scaffolding in high-exposure groups.
• Analyze immunomodulatory and cytoprotective markers, such as clusterin (CLU), in specific formulation groups.

Strengths

• Data from a controlled study with 18 healthy dogs.
• Proteomic analysis compares three distinct CBD delivery matrices.
• License is CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 17.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Label-free quantitative proteomics of canine serum.

Freshness

Last updated 2026-05-13 05:56:02; freshness should be verified.