Clinical and Environmental Correlates of Diabetic Retinopathy from NHANES and Cohort Data

NHANES 2017-2018 and an independent clinical cohort provide data for identifying novel risk factors for diabetic retinopathy (DR). The dataset includes clinical associations with outdoor time, vitamin D levels, electronic device use, and cataract, plus urinary phthalate assessments. Zhiwei Xu authored this integrative analysis, last updated on 2026-05-13.

Use Cases

• Identify novel clinical risk factors for diabetic retinopathy based on associations with outdoor time, vitamin D levels, and electronic device use.
• Investigate the role of environmental exposures by analyzing associations between urinary phthalate metabolites and diabetic retinopathy.
• Explore molecular mechanisms by studying predicted binding interactions between phthalates and target proteins like SRC, BCL2, and MAPK1.
• Validate findings across different data sources by comparing results from the NHANES survey and an independent clinical cohort.

Strengths

• Integrates data from two distinct sources: the nationally representative NHANES 2017-2018 survey and an independent clinical cohort.
• Identifies specific clinical associations with odds ratios (e.g., cataract OR = 11.0) and molecular docking predictions for mechanistic insights.
• Results are published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small (27.5 KB), suggesting it contains summary results rather than raw patient-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

figshare

Collection Method

Analysis of data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) and an independent clinical cohort.

Time Range

Primary data from NHANES 2017-2018.

Freshness

Last updated 2026-05-13 04:39:35; freshness should be verified.

Geography

United States (NHANES) and an unspecified location for the clinical cohort.