L-Se-methylselenocysteine Rat Study: Gut Microbiota and Toxicity Data

Tabular data from a 90-day chronic toxicity study of L-Se-methylselenocysteine in Sprague–Dawley rats. The dataset likely contains results from integrated intestinal microbiome and metabolome analyses, exploring dose-dependent and gender-specific responses. The data was uploaded by Hui Zhang to figshare in March 2026.

Use Cases

• Analyze dose-dependent effects on gut microbiota biodiversity based on the described 0.25–2.25 mg/kg bw/day dose range
• Investigate gender-specific hepatosplenic injury outcomes based on the high-dose toxicity results described for female rats
• Model relationships between probiotic abundance and beneficial metabolite synthesis based on the described gut microbiota-metabolite axis
• Assess hematological and serum biochemical indices for safety evaluation based on the described amelioration of these indices

Strengths

• Data originates from a structured 90-day chronic toxicity study
• Includes integrated analysis of microbiome and metabolome, as described
• Explicitly tests four dose levels (0.25, 0.75, and 2.25 mg/kg bw/day) and gender differences

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (10.6 KB), suggesting limited scope or summary-level data

Provenance

Source

figshare

Collection Method

Data generated from a laboratory study on Sprague–Dawley rats.

Freshness

Last updated 2026-03-19 14:03:07; freshness should be verified