Primary Sjögren's Syndrome Gene Expression Data with 126 Patient Samples

Deep stranded total transcriptome sequencing was performed on minor salivary gland samples from 92 patients with primary Sjögren's syndrome (pSS) and 34 non-SS controls. The dataset, authored by Zhongshan Li and last updated in April 2026, contains results from a genome-wide gene expression analysis, including a constructed competing endogenous RNA (ceRNA) network.

Use Cases

• Analyze differentially expressed genes between pSS and control groups based on the transcriptome sequencing results.
• Study the regulatory function of lncRNAs via ceRNA mechanisms based on the described genome-wide network.
• Validate predicted key lncRNA candidates (e.g., BISPR, LINC00926, HCP5) using the provided expression data.
• Investigate correlations between lncRNA expression and clinical features of pSS as suggested in the description.

Strengths

• Includes data from 126 total patient samples (92 pSS, 34 controls).
• Contains a constructed genome-wide ceRNA network with 3,035 lncRNAs and 10,838 coding genes.
• Three key lncRNA regulatory roles were validated by in vitro experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific patient cohort and tissue samples used.

Provenance

Source

figshare

Collection Method

Deep stranded total transcriptome sequencing of minor salivary gland samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:20; freshness should be verified.

Geography

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