Hepatic Zinc Deficiency and Acute Phase Response in Alcohol-Associated Hepatitis

A transcriptomic zinc signature derived from 11 public datasets, validated in vitro, to examine zinc's role in alcohol-associated hepatitis. The dataset, shared by Scott A. Read under CC-BY-4.0, was last updated on March 18, 2026. It includes a nine-gene signature primarily of metallothionein genes, linking hepatic zinc deficiency to a dampened acute phase response.

Use Cases

• Validate the nine-gene zinc signature in other patient cohorts based on the identified metallothionein genes.
• Model the relationship between hepatic zinc stores and acute phase response genes like SAA1, CRP, and C9.
• Investigate transcriptomic responses to zinc supplementation or depletion in immune cell and hepatocyte cultures.

Strengths

• Derived from 11 publicly available transcriptomic datasets, providing a multi-source foundation.
• Includes a validated nine-gene signature, with specific genes like metallothioneins and SAA1 mentioned.
• Data is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 763.9 KB file size suggests a limited scope of data.

Provenance

Source

figshare, authored by Scott A. Read.

Collection Method

Bioinformatic analysis of public datasets combined with in vitro validation using primary immune cells and hepatocytes.

Freshness

Last updated 2026-03-18 07:36:47; freshness should be verified.