Zebrafish Hnrnpa1 Knockout Model Data on Development and Lipid Metabolism

A 2026 study by Lara U. Jansen describes a novel zebrafish knockout model for RNA binding proteins Hnrnpa1 and Hnrnpa3. The data includes phenotypic and metabolic profiling results from single and double gene mutants. The findings indicate Hnrnpa1 is essential for early zebrafish development and lipid metabolism.

Use Cases

• Studying the role of Hnrnpa1 in early embryonic development based on described morphological phenotypes.
• Investigating genetic compensation in duplicated genes based on the comparison of single and double mutants.
• Analyzing changes in lipid metabolism pathways based on the metabolic profiling results.
• Modeling HNRNPA-associated diseases for future therapeutic studies as mentioned in the description.

Strengths

• Data is associated with a novel zebrafish knockout model, as explicitly stated.
• Includes metabolic profiling data, as mentioned in the description.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The primary data file is a 15.4 KB DOCX document, which suggests limited raw data.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset's scale is very small, which may restrict analytical scope.

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments creating zebrafish knockout models and conducting phenotypic and metabolic analysis.

Freshness

Last updated 2026-06-01.