Hypobaric Hypoxia Effects on Lung Dendritic and CD4+ T Cells in HAPE Models

Figshare dataset by Xuemei Wei contains experimental results on immune cell changes in rodent models of high-altitude pulmonary edema. Data originates from single-cell sequencing, flow cytometry, and in vitro co-culture studies to analyze lung dendritic cells and T-cell immunosuppression under hypobaric hypoxia. The dataset is published under a CC BY 4.0 license.

Use Cases

• Correlate lung dendritic cell counts with hypobaric hypoxia exposure levels in rat and mouse models.
• Analyze CD4+CD25+ T cell proportion changes following TNF-α injection or deficiency in HAPE models.
• Investigate IL-6 production levels in TNF-α deficient mice compared to controls.
• Model the protective role of CD4+ T cells using data from antibody-mediated elimination experiments.

Strengths

• Data is derived from controlled experimental methods including single-cell sequencing and flow cytometry.
• Findings are validated across both rat and mouse models of high-altitude pulmonary edema.
• Dataset is openly shared under a permissive CC BY 4.0 license.

Limitations

• The dataset is very small at 23.0 KB, indicating limited scope and likely summary-level results rather than raw experimental data.
• Specific sample sizes, row counts, and column definitions are not provided, limiting reproducibility and detailed analysis.
• Data is confined to rodent models, and direct applicability to human physiology may be limited.

Provenance

Source

Xuemei Wei via figshare.

Collection Method

Experimental data from single-cell sequencing, flow cytometry, and in vitro co-culture of rodent models.

Freshness

Last updated March 24, 2026.