Hub Genes in Chronic Hepatitis B Immune-Active Phase from Transcriptomic Analysis

Table 4_Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.xlsx is a dataset from figshare, authored by Fangfang Li and last updated on 2026-05-04. It contains results from an integrated bioinformatics and machine learning study analyzing transcriptomic data from chronic hepatitis B patients. The data likely includes identified hub genes, such as SLC24A4, CCR5, IL10RA, and KCNA3, and their correlations with immune features.

Use Cases

• Validating hub gene expression in chronic hepatitis B based on the identified genes SLC24A4, CCR5, IL10RA, and KCNA3.
• Analyzing correlations between gene expression and immune cell infiltration based on the described link to M1/M2 macrophage proportions.
• Screening for FDA-approved compounds targeting specific hub genes based on the described structure-based virtual screening for SLC24A4.
• Training machine learning models for phase-specific biomarker discovery based on the described use of algorithms to identify hub genes.

Strengths

• Dataset is derived from validated clinical samples and independent scRNA-seq datasets as described in the methods.
• Analysis integrated multiple methods, including differential expression, WGCNA, and machine learning, to identify four specific hub genes.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.1 KB, indicating limited scope, likely containing summary results rather than raw expression data.

Provenance

Source

figshare, author Fangfang Li.

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic dataset GSE230397, with validation using scRNA-seq datasets GSE182159 and GSE283471 and western blot.

Time Range

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Freshness

Last updated 2026-05-04 05:31:07; freshness should be verified.

Geography

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