Common Genes Associated with Diabetic Nephropathy and Retinopathy

206 common genes were identified by intersecting differentially expressed genes from diabetic nephropathy and retinopathy transcriptome data. The dataset includes 6 diagnostic genes for diabetic nephropathy and 4 for diabetic retinopathy, along with constructed TF-mRNA-miRNA regulatory networks. Author Juan He uploaded this 19.0 KB Excel file to figshare in April 2026.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic complications using the 206 common genes.
• Analyzing immune cell infiltration differences, such as decreased central memory CD4 T cells in diabetic nephropathy groups.
• Studying gene regulation through the constructed TF-mRNA-miRNA networks, including the key TF EGR1.

Strengths

• Identifies a specific set of 206 common genes between two diabetic complications.
• Lists concrete diagnostic gene candidates, including ATP4A which appears in both conditions.
• Includes results from multiple bioinformatics analyses (enrichment, LASSO, GSEA, immune infiltration).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 19.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Analysis of transcriptome data GSE185011 using bioinformatics tools (limma, ClusterProfiler, Metascape, LASSO).

Freshness

Last updated 2026-04-28 05:24:46; freshness should be verified.