Innate Immune Profiling Data on NK Cells in Hypertensive Males

A dataset from a study profiling innate immune cells in hypertensive and normotensive male subjects. The data was generated using high-dimensional mass cytometry (CyTOF), flow cytometry, and single-cell RNA sequencing. The dataset, authored by Xiaoqi Wang and last updated in April 2026, is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identify specific NK cell subpopulations based on surface marker expression (e.g., CD57, CD62L, CD161).
• Analyze transcriptional heterogeneity within the CD57+CD62L+CD161+ NK cell subset using single-cell RNA sequencing results.
• Investigate associations between NK cell subset composition (e.g., KLRC2high Adaptive vs. FCER1Ghigh Cytotoxic) and hypertension status.
• Explore potential mechanistic pathways, such as IL-15 signaling, related to NK cell survival and apoptosis in hypertension.

Strengths

• Data is validated across two independent cohorts (10 hypertensive/10 normotensive and 10 hypertensive/6 normotensive subjects).
• Multiple high-resolution profiling techniques were used: CyTOF, flow cytometry, and single-cell RNA sequencing.
• The dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The study cohort is limited to male subjects, which may affect generalizability.

Provenance

Source

figshare, author Xiaoqi Wang.

Collection Method

High-dimensional mass cytometry (CyTOF), flow cytometry, and single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs).

Time Range

The temporal coverage of the underlying study is not specified.

Freshness

Last updated 2026-04-16 05:25:50; freshness should be verified.

Geography

The geographic origin of the study subjects is not specified.