Integrating Single-Cell and Bulk RNA Sequencing Data Reveals RGS4 in SF-1 PitNETs

Changxi Han published a dataset on figshare in April 2026, analyzing Steroidogenic Factor-1 (SF-1) lineage Pituitary Neuroendocrine Tumors (PitNETs). The 418.9 KB XLSX file contains results from an integrated analysis of single-cell and bulk RNA sequencing data, identifying a proliferative subgroup characterized by high RGS4 expression. The dataset supports the conclusion that RGS4 promotes tumor proliferation by destabilizing p53.

Use Cases

• Identify molecular subgroups of SF-1 lineage PitNETs based on integrated single-cell and bulk RNA sequencing data mentioned in the description
• Correlate RGS4 expression levels with tumor size and proliferation index as described in the results
• Investigate the functional role of RGS4 in tumor cell proliferation and apoptosis using the provided data
• Study the mechanistic link between RGS4 and p53 ubiquitination and degradation outlined in the description

Strengths

• Dataset is published under a CC-BY-4.0 license, allowing for broad reuse and adaptation
• Analysis integrates both single-cell and bulk RNA sequencing data, as described in the methods

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small at 418.9 KB, indicating limited scope

Provenance

Source

Changxi Han

Collection Method

Integrated analysis of single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic datasets from SF-1 lineage PitNETs.

Freshness

Last updated 2026-04-22 05:49:44; freshness should be verified