MSR1 Gene Expression and Hesperidin Targeting in Osteoarthritis Synovial Tissue

A 19.3 KB Excel file containing results from a multi-omics analysis of osteoarthritis synovial tissue. The dataset, authored by Jinquan Bao and last updated on 2026-05-21, identifies the MSR1 gene as a key regulator and proposes hesperidin as a potential therapeutic compound.

Use Cases

• Validate MSR1 as a biomarker for osteoarthritis based on its differential expression between OA and healthy samples.
• Investigate the relationship between programmed cell death and extracellular matrix genes in joint disease.
• Perform molecular docking studies for drug discovery based on the identified high-affinity binding of hesperidin to MSR1.
• Analyze gene co-expression networks in synovial tissue using the results from Weighted Gene Co-expression Network Analysis (WGCNA).

Strengths

• The analysis is based on RNA-seq data from the GEO databases, a public repository.
• MSR1 was validated with an AUC value greater than 0.7 in distinguishing OA from healthy samples.
• The study employed an integrative multi-omics approach combining WGCNA, differential expression, and PPI network analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 19.3 KB, indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

figshare, author Jinquan Bao.

Collection Method

Analysis of RNA-seq data from GEO databases using WGCNA, differential expression, and PPI network methods.

Freshness

Last updated 2026-05-21 04:35:58; freshness should be verified.