Table 4_Integrative pan-cancer analysis reveals AARS2 as a lactylation-associated biomarke

A 25.8 KB dataset from figshare, last updated March 18, 2026, by author Mingyang Zou. It contains results from an integrative multi-omics analysis of lactylation-related genes in colon adenocarcinoma and pan-cancer cohorts, identifying AARS2 as a key biomarker. The analysis leveraged data from public repositories including TCGA and GEO.

Use Cases

• Validate prognostic signatures for colon adenocarcinoma based on lactylation-related genes.
• Investigate associations between AARS2 expression and tumor microenvironment heterogeneity.
• Perform cross-validation of biomarker findings using immunohistochemistry and in vitro cell line data.
• Analyze the role of lactylation in immune evasion and chemoresistance pathways.

Strengths

• Analysis is based on a curated set of 160 lactylation-related genes.
• Integrates multiple data types including bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics.
• Includes in vitro validation using the HCT116 cell line and immunohistochemistry on clinical specimens.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is small (25.8 KB), suggesting it contains summary or processed results rather than raw data.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Public repositories including TCGA and GEO.

Collection Method

Integrative multi-omics analysis using a multi-step machine learning framework.

Time Range

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Freshness

Last updated 2026-03-18 07:38:34; freshness should be verified.

Geography

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