NHANES Blood Lead Levels and Retinal Vein Occlusion Risk Analysis

The 2005-2008 U.S. National Health and Nutrition Examination Survey (NHANES) data was analyzed for 5,415 participants aged 40 and over. This dataset contains results from a study by Shuai Yang investigating the association between blood lead levels and retinal vein occlusion, including RNA sequencing results from lead-treated endothelial cells. The data was last updated in May 2026.

Use Cases

• Assessing the association between blood lead levels and retinal vein occlusion risk based on NHANES survey data
• Investigating transcriptomic changes in endothelial cells exposed to lead nitrate based on RNA sequencing results
• Exploring the role of Wnt signaling and phosphodiesterase pathways in lead toxicity based on enrichment analysis findings

Strengths

• Analysis is based on a large national survey sample of 5,415 participants
• Includes experimental validation via qRT-PCR for identified genes PRICKLE4 and PLCXD1
• Uses a multi-exposure modeling approach to assess combined effects of heavy metals

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count for the underlying analysis data is unknown, which may limit suitability assessment
• The dataset is very small at 10.4 KB, suggesting it contains summary results rather than raw data

Provenance

Source

NHANES (National Health and Nutrition Examination Survey)

Collection Method

Multivariate logistic regression analysis of survey data combined with laboratory RNA sequencing of HUVECs

Time Range

2005-2008

Freshness

Last updated 2026-05-12 05:42:57

Geography

United States