Long-Term Survival Outcomes for T4N0-3M0 Esophageal Cancer Treatments

A 2011-2018 retrospective cohort study from a single institution compares surgery plus adjuvant chemoradiotherapy (S+CRT) versus definitive chemoradiotherapy (dCRT) for 490 patients with stage T4N0-3M0 esophageal squamous cell carcinoma. The dataset includes 108 patients in the S+CRT group and 382 in the dCRT group, with analyses of overall survival (OS) and progression-free survival (PFS) before and after propensity score matching.

Use Cases

• Compare overall survival (OS) and progression-free survival (PFS) outcomes between the S+CRT and dCRT treatment groups.
• Apply propensity score matching (PSM) analysis to balance cohorts and re-evaluate OS and PFS significance.
• Analyze long-term prognostic differences for T4N0-3M0 stage esophageal squamous cell carcinoma based on treatment modality.

Strengths

• Includes data for 490 patients with a specific cancer stage (T4N0-3M0 ESCC).
• Provides comparative analysis for two distinct treatment groups (108 S+CRT vs. 382 dCRT patients).
• Reports statistically significant P-values (e.g., P = 0.000, 0.003) for survival outcome comparisons.
• Employs propensity score matching, resulting in a matched cohort of 219 patients (138 dCRT, 81 S+CRT).

Limitations

• Small dataset scale at 159.5 KB, indicating limited raw data or a summary document rather than a patient-level table.
• Single-center retrospective design may limit generalizability of findings.
• Unknown row and column structure prevents direct analysis of individual patient features.

Provenance

Source

Shiwang Wen via figshare.

Collection Method

Single-center retrospective cohort study.

Time Range

January 2011 to December 2018.

Freshness

Data covers patients treated through December 2018; the record was last updated in March 2026.

Geography

Patients treated at a single institution (location unspecified).