Pediatric Lung Function Impairment After Tuberculosis Treatment: A Meta-Analysis

Nine studies were included in a systematic review and meta-analysis of lung function outcomes in children after pulmonary tuberculosis treatment. The pooled analysis indicates significant reductions in FEV₁ and FVC z-scores compared to healthy controls, with moderate to high heterogeneity across studies. Author Hanhan Wu published this review on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Estimating the magnitude of lung function impairment in children post-tuberculosis based on pooled z-scores for FEV₁ and FVC.
• Comparing post-tuberculosis pediatric lung function to healthy controls using the reported standardized mean differences (Hedges' g).
• Assessing heterogeneity in pulmonary outcomes across different studies using the reported I² statistics.
• Informing clinical follow-up protocols for children treated for pulmonary tuberculosis based on the evidence of persistent impairment.

Strengths

• Includes data from nine distinct studies, providing a synthesized evidence base.
• Reports specific pooled effect sizes with 95% confidence intervals for key spirometry metrics (FEV₁, FVC, FEV1/FVC).
• Quantifies study heterogeneity with I² statistics ranging from 55% to 98%.
• Has a registered systematic review protocol (PROSPERO CRD420251166413).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The underlying data is a 25.1 KB DOCX file, suggesting the primary content is a summary document rather than a raw dataset.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Scopus up to October 23, 2025.

Time Range

Studies included up to October 2025.

Freshness

Last updated 2026-04-23 05:35:05