Systematic Review of Managed Entry Agreements for Pharmaceuticals, 96 Studies

A systematic review of 96 studies mapping global frameworks for Managed Entry Agreements (MEAs) in pharmaceuticals, conducted by Hussain Abdulrahman Al-Omar and published in 2026. The review synthesizes evidence on system-level components, governance, and implementation challenges from literature up to March 2025. It identifies a significant evidence gap for the Middle East and low-income countries.

Use Cases

• Analyzing geographic coverage of MEA research based on the finding that 43% of studies focused on Europe and 28% on North America
• Identifying common implementation barriers based on themes like inefficient regulatory frameworks (42% of studies) and data infrastructure limitations (41%)
• Researching evidence gaps for Advanced Therapy Medicinal Products (ATMPs) based on the finding that only 15% of studies focused on this area
• Mapping stakeholder representation in policy literature based on the highlighted underrepresentation of academia and civil society

Strengths

• Systematic methodology following PRISMA guidelines, searching MEDLINE and EMBASE from inception to March 2025
• Analysis of 96 included studies, providing a quantitative basis for findings on geographic focus and barrier prevalence
• Clear identification of a 'how-to' gap in the literature, shifting focus from describing barriers to developing solutions

Limitations

• The dataset is a 709.8 KB DOCX document; row count and column-level documentation are absent, limiting suitability assessment for structured analysis
• Data may reflect geographic bias inherent to the source literature, with significant evidence gaps for the Middle East and low-income countries

Provenance

Source

figshare

Collection Method

Systematic review following PRISMA guidelines, with data extracted and synthesized narratively from included studies.

Time Range

Literature from database inception to March 2025.

Freshness

Last updated 2026-04-20 05:23:18; freshness should be verified for ongoing research.

Geography

Global, but with studies predominantly focused on European (43%) and North American (28%) systems.