Metabolite Profiles of PCOS-like Endometrial Organoid Fluids

Metabolomic data from a study analyzing Intra-Organoid Fluid (IOF) and Extra-Organoid Fluid (EOF) from three cases of endometrial organoids. The dataset captures metabolic changes, specifically in amino acid and fatty acid pathways, under simulated high-androgen conditions related to Polycystic Ovary Syndrome (PCOS). It was created by Haoxuan Yang and shared under a CC BY 4.0 license.

Use Cases

• Analyze amino acid metabolism, specifically glutamine levels, in the Extra-Organoid Fluid (EOF) to identify metabolic markers for PCOS-related endometrial dysfunction.
• Compare fatty acid metabolite profiles in the Intra-Organoid Fluid (IOF) across different androgen treatment groups to study cellular lipid changes.
• Investigate correlations between metabolic pathways in IOF and EOF to understand local endometrial dysregulation in a PCOS-like organoid model.

Strengths

• Data is derived from a controlled in vitro model using three cases of clinically healthy endometrial organoids, allowing for focused study of PCOS-like conditions.
• Metabolite profiling was performed using high-throughput quantitative metabolomics, a detailed analytical technique.
• The dataset is openly shared under a permissive CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is very small in scale at 9.7 KB, indicating limited sample size and likely low row/observation count.
• Data is based on an in vitro organoid model with only three cases, which may not fully capture the heterogeneity of human PCOS.
• The specific columns, sample data, and row count are unknown, limiting immediate analytical utility without further investigation.

Provenance

Source

figshare, authored by Haoxuan Yang.

Collection Method

Metabolomic analysis of fluid separated from endometrial organoids cultured under simulated high-androgen conditions.

Freshness

Last updated on 2026-03-25.