Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

A 14.5 KB dataset by Haoran Lu, last updated April 28, 2026, integrates transcriptomic and metabolomic profiles from the rat cerebral cortex. It contains differential expression data for genes and metabolites at 1 day and 7 days post-subarachnoid hemorrhage (SAH) compared to a sham group. The data was generated using whole transcriptome sequencing and untargeted metabolomics assays.

Use Cases

• Identify differentially expressed genes and metabolites based on transcriptomic and metabolomic assays.
• Analyze immune and inflammatory pathway activation based on the Complement and coagulation cascades, TNF, and NOD-like receptor signaling pathways mentioned.
• Investigate metabolic pathway alterations based on Arginine and proline, Arachidonic acid, Folate biosynthesis, Pyrimidine, and Cysteine and methionine metabolism.
• Explore potential therapeutic targets for SAH based on the association of metabolites with immune inflammation, oxidative stress, and endothelial cell damage.

Strengths

• Integrates two omics layers (transcriptome and metabolome) for a multi-faceted view of SAH pathology.
• Reports specific differential expression counts: 982 DEGs and 540 DEMs at SAH 1d vs sham, and 292 DEGs and 254 DEMs at SAH 7d vs SAH 1d.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.5 KB), indicating limited scope and likely summary-level data rather than raw observations.

Provenance

Source

figshare, author Haoran Lu

Collection Method

Data generated via whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex tissue.

Time Range

Covers time points at 1 day and 7 days post-subarachnoid hemorrhage.

Freshness

Last updated 2026-04-28 14:40:42; freshness should be verified.